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FOXO4-DRI at 25 mM concentration selectively induced p53 nuclear exclusion and apoptosis in the senescent Leydig cells, confirmed by Annexin V-FITC/PI apoptosis assays and immunofluorescent staining of Ser15-phospho-p53 foci

DOI Pickart L, Vasquez-Soltero JM, et al

Several studies have shown that antioxidant supplements can alleviate sleep problems in both young and elderly populations, primarily by targeting ROS-generating pathways and scavenging free radicals, thereby preventing cellular damage (David et al., 2023